In ECOLOPES we propose a radical change for city development: instead of minimizing the negative impact of urbanisation on nature, we aim at urbanisation to be planned and designed such that nature – including humans – can co-evolve within the city. We envisage a radically new integrated ecosystem approach to architecture that focuses equally on humans, plants, animals, and associated organisms such as microbiota. ECOLOPES will provide the technology that will help to achieve this vision.